Chipping away at γ-H2AX foci

ChIPping away at gene regulation.

The coordinated regulation of gene expression in higher eukaryotes is complex and poorly understood. Recent technological advances have allowed the first insights into these networks on a genome-wide scale. These investigations have identified transcription factor target sites in the genome and successfully predicted cooperative interactions with other factors. However, a detailed understanding...

Chipping away at stem cells.

U recently, conventional wisdom has held that the lineage potential of stem cells was restricted to the tissue of origin. That is, stem cells derived from tissue A could only give rise to differentiated cells of tissue A and not to differentiated cells of tissues B, C, or D. This notion has been challenged since by a plethora of reports suggesting that stem cells have an inherent plasticity tha...

Chipping Away at Finding Curative Therapy

In clinical cardiology, therapy for the most part is still primarily palliative, whereas relatively few procedures are truly curative. In the early days of invasive electrophysiology, clinicians were excited about the ability to induce supraventricular tachycardia with single, critically timed atrial extrastimuli.1 Soon thereafter, a whole array of mechanisms that induced these tachycardias bec...

Chipping away at the old block

Survivors of acquired brain injury (ABI) are at risk of a range of neuropsychiatric and behavioural disorders. Emotional disturbance, with reactive elements of mood disorder, such as depression and anxiety, appear particularly common. Specific anxiety disorders, such as post-traumatic stress disorder (PTSD) have also been identified. Pain syndromes are also common-particularly in those who have...

Chipping Away at the Perception/Production Interface